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In-vitro experiments on guinea-pig ileum and duodenum preparations using leucine-enkephalin. by Paul W. Mallinson

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Published .
Written in English


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Edition Notes

ContributionsManchester Polytechnic. Department of Biological Sciences.
ID Numbers
Open LibraryOL16700986M

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Botting JH, Salzmann R () The effect of indomethacin on the release of PGE 2 and acetylcholine from guinea-pig isolated ileum at rest and during field stimulation. Br J Pharmacol – Br J Pharmacol –Cited by: A computer simulation program to teach the effects of drugs and electrical stimulation on the enteric nervous system. This program simulates an isolated preparation of the guinea pig ileum, a smooth muscle preparation exhibiting little spontaneous contractile activity, which is extensively used for pharmacological studies. Each dose of ACh was added to an organ bath containing a section of Guinea Pig ileum and Tyrode’s solution at physiological temperature. The response to ACh was measured by the isotonic contractions of the ileum until the maximum response was reached for the dose, using an isotonic force transducer with metal counter-weight of approximately g. for rat and guinea pig ileum preparation to perform schools have involved the use of in vitro experiments using tissues from using guinea pig ileum and rat uterus and duodenum.

There were significant dose and time dependent reductions of the acetylcholine (AC) response with initial stimulatory effects in both the guinea-pig ileum and the mouse duodenum preparations.   Using a modification of the technique of Lewis et al. (3) we have attempted to isolate analogous putative precursors of enkephalin from the myenteric plexus preparation of guinea-pig ileum. Methods Preparations were homogenised in 5 volumes of 10% (v/v) acetic acid containing % (w/v) dithiothreitol or % (v/v) acetic acid in % (v/v. In this experiment pharmacological effect of acetylcholine and carbachol are studied by using an isolated tissue preparation, which is a guinea pig ileum. The contractile property of the smooth muscle is used for the straightforward measurement of the force it produces as an indication of effect. Guinea pig GIT • Strong cardiac sphincter • Proximal colon – Mucus in a deep longitudinal furrow traps bacteria and transports it by anti-peristalsis back to cecum • “Mucus trap” strategy • Less efficient then rabbit’s strategy From: O’Malley B. Clinical anatomy and .

A computer simulation program to teach the effects of drugs and electrical stimulation on the enteric nervous system, using an isolated preparation of the guinea pig ileum. Histamine receptors in the guinea pig ileum. Bertaccini G, Molina E, Zappia L, Zseli J. Histamine and some related compounds acting selectively on H2-or H1 receptors were tested for their ability to contract the guinea pig ileum, in the usual whole ileum preparation and in the longitudinal muscle preparation. Pharmacological reactivity of guinea pig ileum to aqueous extract of Solanum aethiocpicum was determined in vitro. Extract of the vegetable contracted the isolated ileum in a dose dependent fashion. These contractions were inhibited by mepyramine (5x10 .   Interactions of dopamine with a- and adrenoceptors, located either prejunctionally or postjunctionally, have been demonstrated in different animal species and in vitro tissues (dog isolated strips of stomach fundus [1], guinea-pig ileum [2], rat isolated stomach [3, 4], rat duodenum .