Includes bibliographical references and index.
|Statement||edited by Stanley Zucker and Wen-Tien Chen.|
|Series||Current topics in developmental biology -- v. 54|
|Contributions||Zucker, Stanley., Chen, Wen-Tien.|
|The Physical Object|
|Pagination||xxii, 452 p. :|
|Number of Pages||452|
Emmprin (CD), a cell surface regulator of matrix metalloproteinases production and function / Bryan P. Toole The evolving roles of cell surface proteases in health and disease: implications for developmental, adaptive, inflammatory, and neoplastic processes / Joseph A. Madri Shed membrane vesicles and clustering of membrane-bound. Proteases decisively contribute to cancer development and promotion by regulating the activities of growth factors/cytokines and signaling receptors, as well as the composition of the extracellular matrix, thereby suppressing cell death pathways and activating cell survival pathways. In Proteases and Cancer: Methods and Protocols, expert Format: Hardcover. Cell Surface Proteases provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its. Provides an overview of "Cell Surface Proteases" that catalyze the hydrolysis of a protein as it degrades to a simpler substance. This volume provides an overview of the field of cell surface proteases and includes integrins and other adhesion molecules.
This book provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its influence on. Buy Aminopeptidases in Biology and Disease (Proteases in Biology and Disease Book 2): Read Kindle Store Reviews - Proteases found to be associated with the tumor cell surface and which are also correlated with tumor invasion and metastasis include: urokinase plasminogen activator, cathep-sin B, and matrix metalloproteinase Cell surface receptors have been identified for urokinase plasminogen activator and matrix metalloproteinaseCited by: 1. On the cell surface, GRP78 acts as a receptor for activated forms of the proteinase inhibitor, alpha 2-macroglobulin (α 2 M*). α 2 M* binds GRP78 with extremely high affinity and causes cellular proliferation and survival through the activation of the MAPK, PI3K/Akt, cAMP-dependent, and UPR signaling (Quinones et al., ; Gonzalez-Gronow et.
CELL SURFACE PROTEASE, GUANIDINOBENZOATASE, AND CANCER. evidence from the current literature has been discussed on the possible role of proteases, their inhibitors, and specially GB iso-enzyme. Rolf Mentlein, in International Review of Cytology, Abstract. The cell surface has various functions: communicating with other cells, integrating into the tissue, and interacting with the extracellular matrix. Proteases play a key role in these processes. This review focuses on cell-surface peptidases (ectopeptidases, oligopeptidases) that are involved in the inactivation or . The propeptide of most MMPs is cleavable by proteases such as trypsin, plasmin, chymotrypsin and other MMPs. ADAMs participate in a wide variety of cell surface remodeling processes, including ectodomain shedding, regulation of growth . The uPAuPA receptor system of cell surface-localized proteolytic activity has a recognized role in the initial stage of MMP activation, and other serine proteases are also capable ofin vitro MMP activation (63, 64). The TTSPs could play a direct role in MMP activation or an indirect role in localizing and activating other serine proteases.